AB0 compatibility of a donor and recipient is one of the main conditions for successful organ transplantation. A and B antigens, i.e. blood type antigens, are expressed on the surface of almost all cells of the organism.

According to the Landsteiner law, anti-A and anti-B antibodies are circulating in the blood of every human regardless of the presence of blood type antigens. In the majority of people antibodies against AB0 antigens are produced throughout life as a result of the human immune system contacting with the environment. If there is a high titer of antibodies in the recipient blood serum, they induce the process of transplant rejection. To provide graft survival, anti-A/B antibodies have to be decreased to the minimal level (titer reduction). The methods of extracorporeal therapy allow an effective elimination of antigroup antibodies from the patient’s bloodstream.

Anti-A/B antibodies belong to class G and M immunoglobulins. However their blood concentration is minuscule and account for less than a ten thousandth of the total immunoglobulin level. Therefore the usage of methods reducing the concentration of total immunoglobulins is unnecessary. The application of specific sorbents is the most efficient and safe method.